| 摘要 |
<p>Compositions and methods are provided for inhibiting the translation of a capped target mRNA. Antisense oligomers of the invention are targeted to the 5' cap region of the target mRNA and include oligonucleosides, PNAs, or oligonucleotides modified at the 2' position of the sugar. Preferably, said oligomers inhibit protein translation directly via interference with ribosome assembly.</p> |
