| 发明名称 |
Thermodynamically stable crystal form of 4''-deoxy-4''-epi-methylamino avermectin B1a/B1b benzoic acid salt and processes for its preparation |
| 摘要 |
The most thermodynamically stable crystalline form of the benzoic acid salt of 4''-deoxy-4''-epi-methylamino avermectin B1a/B1b as the hemihydrate is obtained by crystallization from organic solvents containing a controlled amount of water.
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| 申请公布号 |
US6486195(B1) |
申请公布日期 |
2002.11.26 |
| 申请号 |
US19950376318 |
申请日期 |
1995.01.20 |
| 申请人 |
MERCK & CO., INC. |
发明人 |
CVETOVICH RAYMOND;MCCAULEY JAMES A.;DEMCHAK RICHARD;VARSOLONA RICHARD J. |
| 分类号 |
C07H17/08;A01N43/90;A01P7/04;C07D493/22;C07H17/04;C07H19/01;(IPC1-7):A61K31/352;A61K31/365;C07D313/00 |
主分类号 |
C07H17/08 |
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