| 摘要 |
Described herein are compounds that are estrogen receptor modulators of Formula I:;and stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors. |
| 主权项 |
1. A compound selected from Formula I: and stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein: X is —CH2— or —CH2CH2—; each R1 is independently selected from halogen, —CN, —OR3, C1-C4 alkyl, —C1-C4 alkyl-OH, C1-C4 fluoroalkyl, —C(═O)OR7, —NHC(═O)R4, —C(═O)NHR7, —SO2R4, —NHSO2R4, and —SO2NHR7; or two R1 together with the carbon atoms to which they are attached form a C2-C7 heterocycloalkyl ring; R2 is H, halogen, —CN, C1-C4 alkyl, —OC1-C4 alkyl, C1-C4 fluoroalkyl or C3-C6 cycloalkyl; each R3 is independently selected from H, C1-C4 alkyl, and C1-C4 fluoroalkyl; each R4 is independently selected from C1-C4 alkyl and C1-C4 fluoroalkyl; each R5 is independently H, halogen, —CN, C1-C4 alkyl, or C1-C4 fluoroalkyl; R6 is H or CH3; each R7 is independently selected from H, C1-C4 alkyl, and C1-C4 fluoroalkyl; m is 0, 1, or 2; and n is 0, 1, 2, or 3. |
