METHODS AND COMPOSITIONS FOR IMPROVING OUTCOMES OF LIPOSOMAL CHEMOTHERAPY

摘要

Materials and methods for treating cancer patients with immunoliposomal chemotherapeutic agents are disclosed. The methods comprise administering to a patient a therapeutically effective amount of an immunoliposome in combination with a chemotherapeutic agent comprising an alkylating agent or an organoplatinum agent. The materials are immunoliposomal chemotherapeutic agents and chemotherapeutic preparations comprising an alkylating agent or an organoplatinum agent, each for use in the disclosed methods.

主权项

1. A method of treating a human patient with a cancer, the method comprising: administering a therapeutically effective amount of a combination of antineoplastic agents, the combination of antineoplastic agents consisting of cyclophosphamide and a pegylated liposome containing encapsulated irinotecan, wherein the administration of the combination of antineoplastic agents comprises at least one treatment cycle, each cycle comprising administering 250 mg/m2 of the cyclophosphamide to the patient followed by administration of a therapeutically effective amount of the pegylated liposome containing encapsulated irinotecan to treat the cancer in the human patient.