| 发明名称 | 1,7-diazacarbazoles and methods of use | ||
| 摘要 | The invention relates to 1,7-diazacarbazole compounds of Formula (I), (I-a) and (I-b) which are useful as kinase inhibitors, more specifically useful as checkpoint kinase 1 (chk1) inhibitors, thus useful as cancer therapeutics. The invention also relates to compositions, more specifically pharmaceutical compositions comprising these compounds and methods of using the same to treat various forms of cancer and hyperproliferative disorders, as well as methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions. | ||
| 申请公布号 | US9440976(B2) | 申请公布日期 | 2016.09.13 |
| 申请号 | US201514743835 | 申请日期 | 2015.06.18 |
| 申请人 | GENENTECH, INC. | 发明人 | Dyke Hazel Joan;Gazzard Lewis;Williams Karen;Chen Huifen;Kintz Samuel;Drobnick Joy;Lyssikatos Joseph P.;Goodacre Simon;Macleod Calum;Ellwood Charles |
| 分类号 | C07D471/14;C07D453/02;A61K31/5377;C07D519/00;A61K31/4375;A61K31/439;A61K31/4545;A61K31/496;A61K31/55;A61K45/06 | 主分类号 | C07D471/14 |
| 代理机构 | Viksnins Harris & Padys PLLP | 代理人 | Viksnins Harris & Padys PLLP |
| 主权项 | 1. A compound or a pharmaceutically acceptable salt thereof selected from the group consisting of: | ||
| 地址 | South San Francisco CA US | ||