Dihydroxybenzene derivatives and antiprotozoal agent comprising same as active ingredient

摘要

Novel compounds below are useful for preventing or treating diseases caused by protozoans. At least one of a compound represented by Formula (I);
(wherein, X represents a hydrogen atom or a halogen atom; R1 represents a hydrogen atom; R2 represents a hydrogen atom or a C1-7 alkyl group; R3 represents —CHO, —C(═O)R5, —COOR5 (wherein R5 represents a C1-7 alkyl group), —CH2OH or —COOH; and R4 represents a C1-16 alkyl group having one or more substituents on a terminal carbon atom and/or non-terminal carbon atom(s), a C2-16 alkenyl group having one or more substituents on a terminal carbon atom and/or non-terminal carbon atom(s), or a C2-16 alkynyl group having one or more substituents on a terminal carbon atom and/or non-terminal carbon atom(s)), an optical isomer thereof, and a pharmaceutically acceptable salt is used.

主权项

1. A compound represented by Formula (I), an optical isomer thereof, or a pharmaceutically acceptable salt thereof: wherein, X represents a hydrogen atom or a halogen atom; R1 represents a hydrogen atom; R2 represents a C1-7 alkyl group; R3 represents —CHO; and R4 represents a C1-16 alkyl group having one or more substituents on a terminal carbon atom and/or non-terminal carbon atom(s), or a C2-16 alkenyl group having one or more substituents on a terminal carbon atom and/or non-terminal carbon atom(s),
wherein the one or more substituents of R4 is each any one of —COORa, wherein Ra represents a C1-7 alkyl group; —O—CO-Rc, wherein Rc represents a C1-7 alkyl group; —O-Rd, wherein Rd represents a C1-7 alkyl group; or, —O—CH2—O—CH3, and —O-HET, wherein HET represents a group formed by removing one hydrogen atom on a carbon or nitrogen atom of heterocyclic compounds.