发明名称 |
Use of EP4 receptor antagonists in the treatment of IL-23 mediated diseases |
摘要 |
This invention relates to a compound with EP4 antagonistic activity, or a pharmaceutically acceptable salt with EP4 receptor antagonistic activities, which is useful in the treatment of immune disease or allergy. This invention also relates to a compound of formula (I), (II), (III), (IV), (Va) or (Vb), or a pharmaceutically acceptable salt thereof with EP4 receptor antagonistic activities, which is useful in the treatment of immune disease or allergy. This invention also relates to a pharmaceutical composition for the treatment of immune disease or allergy which comprises a therapeutically effective amount of a compound of formula (I), (II), (III), (IV), (Va) or (Vb), or a pharmaceutically acceptable salt thereof. Further this invention relates to a method for the treatment of immune disease or allergy in an animal subject including a mammalian subject, which comprises administering to the animal subject including a mammalian subject a compound of the formula (I), (II), (III), (IV), (Va) or (Vb), or a pharmaceutically acceptable salt thereof.; |
申请公布号 |
US9457084(B2) |
申请公布日期 |
2016.10.04 |
申请号 |
US201113580323 |
申请日期 |
2011.02.22 |
申请人 |
RAQUALIA PHARMA INC. |
发明人 |
Kanazawa Kiyoshi;Nonomura Kazuhiko;Okumura Takako;Koizumi Shinichi |
分类号 |
A01N43/42;A61K31/44;A01N37/12;A01N47/28;A61K31/17;C07D513/02;C07D515/02;C07D211/72;A61K45/06;A61K31/38;A61K31/437;A61K31/4412;A61K31/443 |
主分类号 |
A01N43/42 |
代理机构 |
Marshall, Gerstein & Borun LLP |
代理人 |
Marshall, Gerstein & Borun LLP |
主权项 |
1. A method for the treatment of psoriasis in an animal subject including a mammalian subject, by inhibition of IL-23 production, which comprises administering to the animal subject including a mammalian subject, a therapeutically effective amount of the compound, 3-[2-(4-{2-ethyl-4,6-dimethyl-1H-imidazo [4,5-c]pyridin-1-yl}phenyl)ethyl]-1-[(4-methylbenzene)sulfonyl] urea or a pharmaceutically acceptable salt thereof. |
地址 |
Aichi JP |