Method for delivering exenatide to a patient in need thereof

摘要

Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Many embodiments provide a swallowable device for delivering the agents. Particular embodiments provide a swallowable device such as a capsule for delivering drugs into the intestinal wall or other GI lumen. Embodiments also provide various drug preparations that are configured to be contained within the capsule, advanced from the capsule into the intestinal wall and degrade to release the drug into the bloodstream to produce a therapeutic effect. The preparation can be operably coupled to delivery means having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the intestinal wall. Embodiments of the invention are particularly useful for the delivery of drugs which are poorly absorbed, tolerated and/or degraded within the GI tract.

主权项

1. A method for delivering Exenatide to a patient in need thereof, the method comprising:
providing a solid Exenatide dosage shaped as a tissue penetrating member that is enclosed in a swallowable capsule comprising materials which protect the solid Exantide dosage from degradation within the intestinal tract; ingesting the solid Exenatide dosage, wherein the dosage is not degraded in the intestinal tract prior to insertion into an intestinal wall; penetrating the solid Exenatide dosage into the intestinal wall after oral ingestion by the application of mechanical force on the tissue penetrating member wherein the tissue penetrating member is retained within the intestinal wall; and, degrading the solid Exenatide dosage within intestinal wall to release the Exenatide into the intestinal wall and then into the blood stream.