发明名称 |
VECTORS FOR DNA DELIVERY |
摘要 |
The present invention pertains to novel products suitable for use as gene delivery systems in which nucleic acid is linked to a ligand in order to facilitate delivery of the nucleic acid to a target cell or sub-cellular compartment via uptake of the ligand. More particularly, the present inventi on pertains to vectors comprising: (a) a double stranded DNA (dsDNA) having at least one target sequence; and, (b) a chimeric molecule comprising: (i) a sequence specific polyamide (SSP) moiety bound non-covalently to said target sequence; and, (ii) a ligand moiety linked covalently to said sequence specific polyamide. The present invention also pertains to compositions comprising such chimeric molecules and vectors; methods for making such chimeric molecules and vectors; and methods of using such chimeric molecules and vectors, e.g., to deliver nucleic acid vectors to cells or sub-cellular compartments.
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申请公布号 |
CA2408885(A1) |
申请公布日期 |
2001.11.22 |
申请号 |
CA20012408885 |
申请日期 |
2001.05.11 |
申请人 |
ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. |
发明人 |
FATTORI, DANIELA;PESSI, ANTONELLO;INGALLINELLA, PAOLO;BIANCHI, ELISABETTA;KINZEL, OLAF |
分类号 |
A61K48/00;C07B61/00;C07D233/90;C07K1/04;C07K7/06;C07K7/08;C12N15/63;(IPC1-7):C12N15/78;C12N5/10;C07K1/107;C07D403/12;C07D403/14;C07D207/34 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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