发明名称 |
S-Alkylated Hepcidin Peptides and Methods of Making and Using Thereof |
摘要 |
Disclosed herein S-alkylated hepcidin peptides and methods of making and using thereof. In some embodiments, the present invention is directed to an S-alkylated hepcidin peptide having the following Structural Formula IA or IB. In some embodiments, the present invention is directed to a composition comprising at least one S-alkylated hepcidin peptide of the present invention. In some embodiments, the present invention is directed to a method of binding a ferroportin or inducing ferroportin internalization and degradation which comprises contacting the ferroportin with at least one S-alkylated hepcidin peptide of the present invention. In some embodiments, the present invention is directed to a kit comprising at least one S-alkylated hepcidin peptide. |
申请公布号 |
WO2016109363(A1) |
申请公布日期 |
2016.07.07 |
申请号 |
WO2015US67545 |
申请日期 |
2015.12.27 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
RUCHALA, PIOTR;GANZ, TOMAS;NEMETH, ELIZABETA |
分类号 |
C07K7/06 |
主分类号 |
C07K7/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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