DIRECT B-ARYLATION OF CARBONYL COMPOUNDS

摘要

Disclosed is a method for the β-C—H H functionalization of carbonyl compounds that is both selective and broadly applicable. The methods provide direct β-arylation of carbonyl compound with a diverse array of aryl or heteroaryl halides, aryl or heteroryl tosylate, aryl or heteroaryl triflates, or diaryliodonium salts, by palladium catalysis in the presence of a ligand and promoter.

主权项

1. A method of functionalizing a carbonyl compound at a β-carbon with an aryl or heteroaryl group, comprising: contacting a carbonyl compound comprising a β carbon with an aryl or heteroaryl halide, aryl or heteroaryl tosylate, aryl or heteroaryl triflate, or diaryliodonium salt; a palladium catalyst, a ligand, and a promoter, thereby producing arβ-aryl or heteroaryl carbonyl compound.