Tissue eversion apparatus and tissue closure device and methods for use thereof

摘要

Methods and apparatuses for closure of vascular punctures or other openings in bodily tissues. The apparatuses and methods described herein are configured for everting a portion of tissue around a puncture site for wound closure on the external surface of the wound. For example, the tissue eversion apparatus may be configured for drawing up a portion of a vessel surrounding a venous or arterial puncture and orienting the inner surface of the vessel at least partially outward so that a closure element may be placed around the inverted region on the exterior surface of the vessel. In some embodiments, the devices are bioabsorbable.

主权项

1. A method of closing a puncture in a body tissue having an inner wall and an outer wall, the method comprising:
positioning a tissue eversion apparatus in an opening of the puncture, the tissue eversion apparatus being configured to form an everted tissue region around the puncture, the tissue eversion apparatus including:
a solid elongate member configured to be positioned in the puncture, the elongate member having a proximal end, a distal end, a distal surface, and an exterior surface extending between the distal end and the proximal end, the distal surface abutting the exterior surface at the distal end; anda tissue engaging portion comprising at least two tissue engaging prongs that extend radially outwardly in a proximal direction and that are disposed on the exterior surface of the elongate member at or near the distal end and on opposite sides of the elongate member,
wherein the at least two tissue engaging prongs are configured to locate and engage a portion or portions of the tissue surrounding the puncture, and on opposite lateral sides of the opening, as the apparatus is withdrawn relative to the puncture; withdrawing a portion of the tissue eversion apparatus, which has previously passed through the opening to position the tissue eversion apparatus, proximally from the opening such that the tissue engaging prongs pierce the tissue from the inner wall towards the outer wall and draw the tissue up to form an everted tissue region around the opening in the body tissue, the tissue engaging prongs extending proximally and radially outwardly from the elongate member in a pre-deployed configuration and following engagement with the tissue and withdrawal of the elongate member proximally to form the everted tissue; positioning a closure element around at least a portion of the everted tissue region so as to close the opening; and releasing the everted tissue region from the tissue engaging prongs.