SAFE AND EFFECTIVE BETA-LACTAMASE DOSING FOR MICROBIOME PROTECTION

摘要

The present invention relates to, inter alia, safe and effective doses of a beta-lactamase for, e.g. microbiome protection.

主权项

1. A method of protecting a patient's gastrointestinal microbiome, comprising administering an effective amount of a pharmaceutical composition comprising a beta-lactamase to a patient in need thereof, wherein:
the patient is undergoing treatment or has recently undergone treatment with a beta-lactam antibiotic, optionally selected from a penicillin and a cephalosporin; the beta-lactamase comprises an amino acid sequence having at least 95% identity with SEQ ID NO: 1, and the effective amount of beta-lactamase is between about 5 and about 200 mg.