METHOD TO SOLUBILIZE CURCUMINOIDS IN WATER

摘要

A method of solubilizing curcuminoids is disclosed wherein the method uses polyvinyl pyrrolidone and sodium bis (2-ethylhexyl) sulfosuccinate and the aqueous solubility of curcumin/curcuminoid mixtures is enhanced to more than 10%-15% w/v in water. The present invention also pertains to a curcuminoids composition characterised by not less than 10% w/v, more specifically between 10%-15% w/v aqueous solubility of curcuminoids in water.

主权项

1. A method of solubilising curcumin/curcuminoid mixtures whereby aqueous solubility of curcumin/curcuminoid mixtures is enhanced to more than 10%-15% w/v in water using polyvinyl pyrrolidone (PVP) and dioctyl sulfosuccinate (AOT) or Docusate sodium, said method comprising steps of
a) Stirring continuously at room temperature a mixture of polyvinyl pyrrolidone (PVP) and dioctyl sulfosuccinate (AOT) taken in ethanol till the solution of said mixture becomes clear; b) Adding curcuminoids at room temperature to the solution of step a followed by continuous stirring for 15 hours to further get a clear solution; c) Evaporating the ethanol in solution of step b using Rota evaporator and further adding distilled water to get a clear mixture; d) Removing any insoluble material from the clear mixture of step c by filtration; and e) Spray drying the resulting mixture of step d at 140-150° C. using a spray dryer to get the final product of solubilised curcuminoids wherein the assay of curcuminoids in the final product by HPLC indicates not less than 10% why of curcuminoids.