| 主权项 |
1. A method of treating a tumor or cancer that overexpresses AKT in a mammal comprising administering to the mammal an effective amount of a composition comprising:
(i) a compound of formula I-IV: wherein each R2′, R3′ and R5′ are independently hydrogen, optionally substituted phosphate or phosphonate; acyl; alky; amide, sulfonate ester including alkyl or arylalkyl; sulfonyl, methanesulfonyl; benzylsulfonyl; optionally substituted arylsulfonyl; a lipid, a phospholipid; an amino acid; a carbohydrate; a peptide; or cholesterol; or other pharmaceutically acceptable leaving group that, in vivo, provides a compound wherein R2′, R3′ and R5′ is independently H or mono-, di- or tri-phosphate; wherein Rx and Ry are independently hydrogen, optionally substituted phosphate; acyl; amide, alkyl; aromatic, polyoxyalkylene such as polyethyleneglycol, optionally substituted arylsulfonyl; a lipid, including a phospholipid; an amino acid; a carbohydrate; a peptide; or cholesterol; or other pharmaceutically acceptable leaving group; R1 and R2 each are independently H, optionally substituted straight chained, branched or cyclic alkyl, alkenyl, or alkynyl, CO-alkyl, CO-alkenyl, CO-alkynyl, CO-aryl or heteroaryl, CO-alkoxyalkyl, CO-aryloxyalkyl, CO-substituted aryl, sulfonyl, alkylsulfonyl, arylsulfonyl, aralkylsulfonyl; wherein the compound of formula I-IV is administered to said mammal in an amount of at least 10 mg/m2; (ii) a compound of formula V:wherein
R1, R2, R3, R4, and R5 each are independently H, optionally halogenated, substituted straight chained, branched or cyclic alkyl (including lower alkyl), alkoxyl, alkenyl, or alkynyl, aryl, CO-alkyl, CO-alkenyl, CO-alkynyl, CO-aryl or heteroaryl, CO-alkoxyalkyl, CO-aryloxyalkyl, CO-substituted aryl, sulfonyl, alkylsulfonyl, arylsulfonyl, aralkylsulfonyl. |
