Compositions including anthocyanin or anthocyanidin for the prevention or treatment of articular cartilage-associated conditions

摘要

Methods of treating an arthritic joint of a subject, including administering a pharmaceutical composition by injection into the arthritic joint, wherein the composition includes an anthocyanin or anthocyanidin, glucose, and a pharmaceutically acceptable carrier.

主权项

1. A method of inhibiting interleukin-1 (IL-1) induced glycosaminoglycoside (GAG) release in an arthritic joint of a subject, comprising administering into the arthritic joint of the subject, by an intra-articular injection, a composition that is a solution consisting of an anthocyanin, glucose and a pharmaceutically acceptable carrier, wherein the concentration of said glucose in said solution is 5%, and wherein the anthocyanin is cyanidin-3-glucoside and said cyanidin-3-glucoside is administered at a dose of 0.002 mg to 100 mg per joint.