CD86 antagonist multi-target binding proteins

摘要

This disclosure provides a multi-specific fusion protein composed of a CD86 antagonist binding domain and another binding domain that is an IL-10 agonist, an HLA-G agonist, an HGF agonist, an IL-35 agonist, a PD-1 agonist, a BTLA agonist, a LIGHT antagonist, a GITRL antagonist or a CD40 antagonist. The multi-specific fusion protein may also include an intervening domain that separates the other domains. This disclosure also provides polynucleotides encoding the multi-specific fusion proteins, compositions of the fusion proteins, and methods of using the multi-specific fusion proteins and compositions.

主权项

1. A multi-specific fusion protein, comprising a CD86 binding domain linked to a heterologous binding domain by an intervening domain, wherein the heterologous binding domain is an IL-10 or a monoIL10 that is an IL-10 molecule having a short linker that separates two subdomains of the IL-10 molecule, and wherein the CD86 binding domain comprises heavy chain and light chain variable regions of a CD86-specific antibody binding domain.