Bacteriophage gene 3 protein compositions and use as amyloid binding agents

摘要

The invention relates to agents and to pharmaceutical compositions for reducing the formation of amyloid and/or for promoting the disaggregation of amyloid proteins. The compositions may also be used to detect amyloid.

主权项

1. A pharmaceutical composition comprising a fusion protein that comprises an amyloid-binding polypeptide and an immunoglobulin IgG constant region,
wherein the amyloid binding polypeptide is present in an amount sufficient to treat a disease or disorder associated with misfolded and/or aggregated amyloid protein and a pharmaceutically acceptable carrier, and wherein the polypeptide comprises at least one of:
(a) a wild type g3p;(b) an amyloid-binding fragment of wild type g3p; or(c) a mutant of (a) or (b) that retains the ability to bind to amyloid.