Polypeptide inhibitors of HSP27 kinase and uses therefor

摘要

The present invention provides polypeptide inhibitors of HSP27 kinase, compositions thereof, and methods for using such polypeptides and compositions for various therapeutic uses.

主权项

1. A method for treating a disease, disorder or a condition in a subject in need thereof characterized by inhibiting excretion of TNF-α from monocytes selected from the group consisting of osteoarthritis, rheumatoid arthritis, gliosis, and scar formation in the central nervous system, the method comprising the step of:
administering a therapeutic amount of a composition comprising an isolated polypeptide and a pharmaceutically acceptable carrier; wherein the polypeptide comprises a sequence Z1-X1-X2-X3-X4-X5-X6-X7-X8-X9-X10-Z2 (Formula I) (SEQ ID NO: 69); wherein Z1 and Z2 are independently absent or are transduction domains; and wherein X1-X2-X3-X4-X5-X6-X7-X8-X9-X10 is an amino acid sequence selected from the group consisting of the amino acid sequence KALARQLGVAA (SEQ ID NO: 62), the amino acid sequence KALNRQLAVAA (SEQ ID NO: 66), and the amino acid sequence KALNRQLGVA (SEQ ID NO: 68).