Diazaspirocycloalkane and azaspirocycloalkane

摘要

The invention provides novel compounds having the general formula (I);
wherein R1, R2, Y and W are as described herein, compositions including the compounds and methods of using the compounds.

主权项

1. A compound of formula (I) wherein R1 is phenylalkyl substituted with R8, R9 and R10; R2 is —C(O)—R3; Y is —OC(O)—; W is R3 is;and
R8, R9, and R10 are independently selected from H, alkyl, hydroxyalkyl, haloalkyl, cycloalkyl, cycloalkylalkyl, cycloalkylalkoxy, cycloalkoxy, cycloalkoxyalkyl, cycloalkylalkoxyalkyl, alkoxy, alkoxyalkyl, haloalkoxy, haloalkoxyalkyl, alkoxyalkoxy, alkoxyalkoxyalkyl, halogen, hydroxy, cyano, alkylsulfonyl, cycloalkylsulfonyl, substituted aminosulfonyl, substituted amino and substituted aminoalkyl, wherein substituted aminosulfonyl, substituted amino and substituted aminoalkyl are substituted on the nitrogen atom with one to two substituents independently selected from hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, hydroxyalkyl, alkoxyalkyl, alkylcarbonyl and cycloalkylcarbonyl; or a pharmaceutically acceptable salt thereof.