| 主权项 |
1. A compound of formula I,wherein:
any two of A, B and D are N and the other one is CH; Z is selected from the group consisting of —C(O)— and —S(O)2—; X is halogen or N, with the proviso that when X is halogen, R1 and R2 in formula I are absent; R1 and R2 are each independently selected from the group consisting of H, linear or branched alkyl having 1 to 6 carbon atoms, linear or branched heteroalkyl having 1-6 carbon atoms in which 1 to 2 of the non-terminal carbon atoms independently are replaced by O, NH, or S; R3 is H; R4 is selected from the group consisting of aryl and fused aryl containing 5 to 10 atoms; wherein said aryl or fused aryl is optionally and independently mono-, di- or poly-substituted with halogen; R5 is selected from the group consisting of linear or branched alkyl having 1 to 6 carbon atoms, linear or branched heteroalkyl having 1 to 6 carbon atoms in which 1 to 2 of the non-terminal carbon atoms independently are replaced by O, NH, or S, cycloalkyl containing 4 to 8 carbon atoms, 5- to 8-membered heterocycloalkyl containing 1 to 2 heteroatoms independently selected from the group consisting of O, N and S; m is 0, 1 or 2; and n is 1, or a racemate or a stereoisomer, or a pharmaceutically acceptable salt or solvate thereof. |
