| 发明名称 | Pyrrole inhibitors of S-nitrosoglutathione reductase as therapeutic agents | ||
| 摘要 | The present invention is directed to inhibitors of S-nitrosoglutathione reductase (GSNOR), pharmaceutical compositions comprising such GSNOR inhibitors, and methods of making and using the same. | ||
| 申请公布号 | US9498466(B2) | 申请公布日期 | 2016.11.22 |
| 申请号 | US201514922928 | 申请日期 | 2015.10.26 |
| 申请人 | Nivalis Therapeutics, Inc. | 发明人 | Wasley Jan;Rosenthal Gary J.;Sun Xicheng;Strong Sarah;Qiu Jian |
| 分类号 | A61K31/4178;A61K31/4025;A61K31/40;C07D207/327;C07D401/04;C07D401/10;C07D401/12;C07D401/14;C07D403/04;C07D403/10;C07D403/12;C07D403/14;C07D405/04;C07D405/10;C07D405/12;C07D409/04;C07D409/10;C07D409/12;C07D409/14;C07D413/04;C07D413/10;C07D413/12;C07D413/14;C07D417/04;C07D417/10;C07D417/14;C07D207/337;A61K31/402 | 主分类号 | A61K31/4178 |
| 代理机构 | Swanson & Bratschun, L.L.C. | 代理人 | Swanson & Bratschun, L.L.C. |
| 主权项 | 1. A method of inhibiting the activity of the enzyme S-nitrosoglutathione reductase (GSNOR) comprising the step of contacting said enzyme with a compound of formula I or pharmaceutically acceptable salts thereof: wherein: Ar is selected from the group consisting of phenyl and thiophen-yl; R1 is selected from the group consisting of unsubstituted imidazolyl, substituted imidazolyl, chloro, bromo, fluoro, hydroxy, and methoxy; R2 is selected from the group consisting of hydrogen, methyl, chloro, fluoro, hydroxy, methoxy, ethoxy, propoxy, carbamoyl, dimethylamino, amino, formamido, and trifluoromethyl; and X is selected from the group consisting of CO and SO2. | ||
| 地址 | Boulder CO US | ||