CELL DIFFERENTIATION INDUCING SUBSTANCE

摘要

PURPOSE:To obtain a monokine such as granulocyte macrophage colony stimulation factor useful as a medicine by adding a cell differentiation-inducing substance containing staurosporine to macrophage and culturing the macrophage. CONSTITUTION:Macrophage is cultured by adding a cell differentiation-inducing substance containing staurosporine. The staurosporine can be separated from a filtrate of a culture liquid obtained e.g. by culturing Streptomyces diastato- chromogenes IFO 13389 at pH6-7 and about 30 deg.C for 48hr.