PROCESS FOR SYNTHESIZING CARBAPENEM ANTIBIOTICS

摘要

A process for the direct crystallization of a compound of formula (I) or a pharmaceutically acceptable salt thereof, is disclosed, wherein R<1> and R<2> represent H, C1-10 alkyl, aryl or heteroaryl, or substituted C1-10 alkyl, aryl or heteroaryl and X<+> represents a charge balancing group, comprising extracting a solution containing a crude compound of formula (I) or (Ia) or a pharmaceutically acceptable salt thereof, wherein each X<+> is a charge balancing group, and R<1> and R<2> are as described above with a C4-10 alcohol, collecting and crystallizing the resulting aqueous phase to produce a crystalline compound of formula (I).