| 摘要 |
PURPOSE: To obtain a new compound having a platelet activation factor- antagonizing action and a thromboxane A2 synthesis-inhibiting action, useful as an antiallergic agent or antiinflammatory, low in toxicity, and exhibiting the effects on both oral administration and parenteral administration. CONSTITUTION: A compound of the formula [R1 is H, phenyl, etc.; R2 is -COO- A-(3-pyridyl) (A is 3-6C linear alkylene, alkenylene); R3 is 2-10C alkyl, alkenyl, etc.; R4 is R2 , -CO-B-R5 (R is O, -NH-; R5 is lower alkyl)], e.g. 2,6-dimethyl-4- isopropyl-1,4-dihydropyridine-3,5-dicarboxylic acid bis[3-(3-pyridy)propyl] ester. The compound of formula I wherein R1 is H is obtained by reacting an aldehyde compound of formula: R3 CHO with an acetoacetic acid ester of formula: CH3 COCH2 R2 and a 2-aminocrotonic acid ester of formula: CH3 C(NH2 )=CHR4 . |
