Method of synthesizing camptothecin-relating compounds

摘要

A process for preparing 2'-amino-5'hydroxypropiophenone to synthesize camptothecin analogs as depicted in the diagram as disclosed, where R is a protective group which can be deprotected by a catalytic reduction. Camptothecin analogs such as 7-ethyl-10-hydroxycamptothecin are key intermediates in synthesis of irinotecan, a type of anti-cancer topoisomerase inhibitor. (62) Divided out of 527615