In vitro screening for compounds useful for treating diabetes, obesity and insulin resistance, from their ability to modulate expression or activity of the E2IG4 gene

摘要

In vitro method for screening or identifying compounds (A) useful in treatment of diabetes (or its complications), obesity or insulin resistance by contacting test compounds with a cell that expresses the gene E2IG4 and selecting compounds that modify the expression level of this gene. An independent claim is also included for a similar method in which the cell expresses a reporter gene (RG) operably linked to the promoter of the E2IG4 gene and compounds that modulate expression of RG are selected. ACTIVITY : Antidiabetic; Anorectic. No details of tests for these activities are given. MECHANISM OF ACTION : RNAi; RNA interference; Antisense oligonucleotide inhibitor.