发明名称 |
Ammonia-Specific 5'-Xmp Aminase Mutant |
摘要 |
Disclosed herein are ammonia-specific 5'-XMP aminase mutants and a method for preparing the same. A mutation is introduced into the active site of glutamine-dependent catalysis in 5'-XMP aminase. The resulting 5'-XMP aminase mutant is devoid of the glutamine-dependent activity and specifically reacts with external ammonia in converting 5'-XMP into 5'-GMP. Thus, the ammonia-specific 5'-XMP aminase mutant is stabler within cells compared to the wild type, and can be useful in the industrial conversion of 5'-XMP into 5'-GMP.
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申请公布号 |
US2008318278(A1) |
申请公布日期 |
2008.12.25 |
申请号 |
US20060097104 |
申请日期 |
2006.12.14 |
申请人 |
CJ CHEILJEDANG CORPORATION |
发明人 |
PAN JAE-GU;JUNG HEUNG-CHAE;KIM EUI-JOONG;LEE HAN-SEUNG;PARK YOUNG HOON;KIM HYOUNG SUK;HAN JONG-KWON;LEE JIN NAM;OH KI-HOON;KIM JEONG HWAN;OH YOON-SUK;SIM JAE ICK;HONG KUK-KI;CHOI KYUNG OH;KIM HYUN SOO;BAEK MIN-JI;KANG TAE SUN |
分类号 |
C12P19/30;C07H21/02;C07H21/04;C12N1/21;C12N9/10;C12N15/64 |
主分类号 |
C12P19/30 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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