Compositions and methods for glioblastoma treatment

摘要

The present disclosure concerns an oncolytic virus for the treatment of cancer, such as in brain cancer, for example glioblastoma. The oncolytic virus may exhibit reduced levels of neurotoxicity. The oncolytic virus may be an isolated viral particle capable of producing a cDNA polynucleotide that includes a sequence according to SEQ ID NO: 1 when the virus is in a host cell. The oncolytic virus may be an isolated viral particle that includes an RNA polynucleotide that includes a sequence according to SEQ ID NO: 2. The oncolytic virus may be an isolated viral particle having a genome that includes open reading frames that encode: proteins having sequences comprising SEQ ID NOs: 3, 4, 5, 6 and 7; or variants thereof.

主权项

1. A method for inducing an immunogenic response in a patient, the method comprising administering to the patient an isolated viral particle having a genome comprising open reading frames that encode:
a protein comprising SEQ ID NO: 3; a protein comprising SEQ ID NO: 4; a protein comprising SEQ ID NO: 5; a protein comprising SEQ ID NO: 6; and a protein comprising SEQ ID NO: 7.