| 发明名称 | Anti-tumor adjuvant therapy | ||
| 摘要 | A chimeric peptide construct having a cell penetrating peptide linked to a pro-apoptotic peptide. The construct can be used for treating a tumor in combination with an anti-tumor agent. Also disclosed is a method for treating a tumor with the chimeric peptide construct and a chemotherapeutic agent. | ||
| 申请公布号 | US9364514(B2) | 申请公布日期 | 2016.06.14 |
| 申请号 | US201214366504 | 申请日期 | 2012.12.27 |
| 申请人 | Institute Curie;Universite Pierre et Marie Curie (Paris 6) | 发明人 | Rebollo Garcia Angelita;Nemati Fariba;Decaudin Didier |
| 分类号 | C07K7/08;A61K38/00;A61K38/10;C07K14/47;C12N9/64;A61K31/337;A61K31/513;A61K31/664;A61K31/704;A61K33/24 | 主分类号 | C07K7/08 |
| 代理机构 | Cesari and McKenna LLP | 代理人 | Cesari and McKenna LLP |
| 主权项 | 1. A chimeric peptide construct for use in treating a tumor in combination with an anti-tumor agent, wherein the chimeric peptide construct is selected from the group consisting of:(SEQ ID NO: 29)VKKKKIKREIKI-YVETLDDIFEQWAHSEDL,(SEQ ID NO: 30)VKKKKIKREIKI-YIETLDDILEQWARSEDL,(SEQ ID NO: 31)VKKKKIKAEIKI-YVETLDDIFEQWAHSEDL,(SEQ ID NO: 32)VKKKKIKAEIKI-YIETLDDILEQWARSEDL,(SEQ ID NO: 33)VKKKKIKKEIKI-YVETLDDIFEQWAHSEDL,(SEQ ID NO: 34)VKKKKIKKEIKI-YIETLDDILEQWARSEDL,(SEQ ID NO: 35)VKKKKIKNEIKI-YVETLDDIFEQWAHSEDL,and(SEQ ID NO: 36)VKKKKIKNEIKI-YIETLDDILEQWARSEDL. | ||
| 地址 | Paris FR | ||