Substituted benzofuran compounds and methods of use thereof for the treatment of viral diseases

摘要

The present invention relates to compounds of formula I that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system. (I)

主权项

1. A compound having the formula: or a pharmaceutically acceptable salt thereof, wherein:
X is A is fluorophenyl;B is a) hydrogen;
b) Ar;c) C1-C6 alkyl-Ar;d) —CHRa—Ar; ore) cyclopropyl;Ar is a 5-6 membered monocyclic aromatic ring with 0 or 1 heteroatom ring atoms independently selected from N and S, optionally substituted with 1 or 2 substituents independently selected from C1-C6 alkoxy, halo, and cyano;D is H or NR3SO2R4;R2 is C1-C6 alkyl;R3 is C1-C6 alkyl;R4 is C1-C6 alkyl;Ra is C1-C6 hydroxyalkyl, or alkylalkoxy;Rc is hydrogen, C1-C6 alkyl, alkylalkoxy, or —CH2NHC(O)CH3;Rd is hydrogen, F, Cl or C1-C6 alkyl;Re and Rf are independently hydrogen or C1-C6 alkyl; andRg is hydrogen or C1-C6 alkoxy.