Toll-Like Receptor 4 (Tlr-4) Agonist Peptides For Modulating Tlr-4 Mediated Immune Response

摘要

Peptides including an amino acid sequence of a fragment of mammalian Toll-like receptor-4 (TLR-4), analogs and derivatives thereof, and pharmaceutical compositions including these peptides. Methods for modulating a TLR-4 mediated immune response, particularly stimulating TLR-4 mediated immune response, thereby treating infectious diseases and cancer.

主权项

1. An isolated peptide of 7-25 amino acids comprising the amino acid sequence as set forth in TIIX1VX2VLX3VLVVX4V (SEQ ID NO: 2) wherein X1 is selected from the group consisting of Gly, Ser, Gln and Ala; and X2, X3 and X4 are each independently selected from the group consisting of Ser, Gln and Ala, or an analog having at least 80% identity to the isolated peptide, or a fragment, chemical derivative or a salt thereof.