| 发明名称 |
Tubulysin derivatives |
| 摘要 |
Novel tubulysin derivatives which may be useful as cytotoxic agents to provide therapeutic benefits in the treatment of various types of cancers, alone, as drug conjugates or in combination with other chemotherapies are provided. |
| 申请公布号 |
US9427479(B2) |
申请公布日期 |
2016.08.30 |
| 申请号 |
US201514683196 |
申请日期 |
2015.04.10 |
| 申请人 |
MedImmune LLC |
发明人 |
Gingipalli Lakshmaiah;Toader Dorin;Wang Fengjiang |
| 分类号 |
A61K38/07;A61K47/48;C07K5/033;A61K38/05;C07K5/02;C07K5/062;C07D417/12;C07D417/14 |
主分类号 |
A61K38/07 |
| 代理机构 |
|
代理人 |
Kopp Daniel |
| 主权项 |
1. A compound having the structure of Formula I: or a pharmaceutically acceptable salt thereof, wherein: R1 is CH3 or CH2CH3, R2 is H or CH3, R3 is H or NH2 and n is 1 or 2. |
| 地址 |
Gaithersburg MD US |
