Therapeutic miRNAs for treating heart and skeletal muscle diseases

摘要

The present disclosure describes the role for miR-322(424)/503 in the differentiation of cardiac precursor cells. Thus, the use of these molecules in the programming of resident stem/progenitor cells into cardiomyocytes, both in vitro and in vivo. Such methods find particular use in the treatment of patients post-myocardial infarction to prevent or limit scarring and to promote myocardial repair.

主权项

1. A method of programming a residential embryonic stem cell or a residential cardiac progenitor cell into cardiac fibroblast comprising contacting said cell with miR-322/424 and/or miR-503, as well pri-miRNAs and pre-miRNAs thereof wherein said contacting results in programming of said cell into a cardiac fibroblast.