INJECTION PARADIGM FOR ADMINISTRATION OF BOTULINUM TOXINS

摘要

Disorders such as headaches can be treated by administration of a botulinum toxin to a patient suffering therefrom, such as a migraine headache. A combined a fixed site/fixed dose and an optional follow the pain variable dosage and injection site paradigm is disclosed for optimizing clinical effectiveness of botulinum toxin administration for patients suffering headache, particularly chronic migraine.

主权项

1. A method for alleviating or reducing the occurrence of a headache in a patient with chronic migraine headaches, the method comprises:
localizing one or more administration target; isolating the one or more administration target; administering a therapeutically effective amount of a clostridial toxin to the isolated one or more administration target; wherein the one or more administration target comprises the frontalis, corrugator, procerus, occipitalis, temporalis, trapezius and cervical paraspinal muscles; wherein the administrating step is by injection and wherein the administering step comprises limiting the injection to a defined tissue depth and injection angle.