BIOCOMPATIBLE POLYMERIC SYSTEM FOR TARGETED TREATMENT OF THROMBOTIC AND HEMOSTATIC DISORDERS

摘要

A biocompatible polymer to which a plurality of clot-modulating peptides (CMPs) are bound. The polymer comprises repeating units of hydrophilic monomers and display monomers to which the CMPs are bound. For example, the CMPs can be fibrin binding peptides (FBPs) that enhance clot formation by cross-linking that occurs within and between fibers by the plurality of fibrin-binding peptides during fibrin polymerization. The polymers of the invention can be used to modulate clotting in a variety of ways via multivalent display of fibrin-binding peptides and other clot-binding and clot-modulating moieties on polymer or co-polymer backbones. In addition to clot-modulating moieties, imaging agents and therapeutic agents can be conjugated to the polymers to facilitate imaging of blood flow and thrombosis, and for treatment of clotting-related disorders.

主权项

1. A biocompatible polymer comprising repeating units that form a backbone, wherein the repeating units comprise:
(a) a hydrophilic monomer and a display monomer, and (b) a plurality of pendant clot-modulating peptides (CMPs) bound to the display monomer.