Method of treating colorectal cancer that expresses a mutated APC gene by administering erythromycin or tylosin

摘要

The present invention includes methods for treating or preventing a cancer in a mammal comprising administering to the mammal a therapeutically effective amount of a macrolide antibiotic such as tylosin, erythromycin, oleandomycin, spiramycin, and pharmaceutically acceptable salts and derivatives thereof.

主权项

1. A method for treating a human subject having colorectal cancer that expresses a mutated APC gene that contains a premature stop codon caused by a nonsense mutation, comprising treating the human subject by administering to the human subject, as active agent, a therapeutically effective amount of tylosin or erythromycin, or a pharmaceutically acceptable salt or prodrug of tylosin or erythromycin, wherein said treating excludes preventing the colorectal cancer.