| 发明名称 | Microcin and uses thereof | ||
| 摘要 | Microcin MccPDI and bacteria harboring the mcpM gene which encodes MccPDI, limit growth of and/or kill pathogenic bacteria such as pathogenic Escherichia coli (E. coli) and/or Shigella bacteria via proximity-dependent inhibition (PDl). | ||
| 申请公布号 | US9492500(B2) | 申请公布日期 | 2016.11.15 |
| 申请号 | US201314407975 | 申请日期 | 2013.06.14 |
| 申请人 | Washington State University | 发明人 | Call Douglas R.;Eberhart Lauren;Brayton Kelly A.;Besser Thomas E.;Sawant Ashish;Orfe Lisa |
| 分类号 | C12N1/12;C12N1/20;A61K38/16;C07K14/245;A01N63/00;A01N63/02;A61K35/74;C11D3/38;C12N7/00 | 主分类号 | C12N1/12 |
| 代理机构 | Whitman, Curtis & Cook, P.C. | 代理人 | Whitman, Curtis & Cook, P.C. |
| 主权项 | 1. A method of killing or decreasing adverse effects of pathogenic Escherichia coli (E. coli) and/or Shigella bacteria, comprising identifying a surface or subject known to or suspected of contamination with said pathogenic E. coli and/or Shigella bacteria; and contacting said pathogenic E. coli and/or Shigella bacteria with microcin MccPDI having SEQ ID NO: 24 or a functional variant thereof, oran organism that produces MccPDI SEQ ID NO: 24 or a functional variant thereof,wherein said functional variant has a sequence at least 95% identical to SEQ ID NO: 24. | ||
| 地址 | Pullman WA US | ||