| 发明名称 | Compositions and methods of treating cancer | ||
| 摘要 | A method of inhibiting neoplastic, cancer, and/or tumorgenic cell proliferation, cell growth and motility in a subject includes administering to a cancer cell expressing Pro-PrP and FLNa a therapeutically effective amount of a Pro-PrP regulating agent. | ||
| 申请公布号 | US9492472(B2) | 申请公布日期 | 2016.11.15 |
| 申请号 | US200913141437 | 申请日期 | 2009.12.23 |
| 申请人 | Case Western Reserve University | 发明人 | Sy Man Sun;Xin Wei;Li Chaoyang;Yu Shuiliang;Yin Shaoman |
| 分类号 | A61K39/00;A61K31/7088;A61K31/00;A61K38/17 | 主分类号 | A61K39/00 |
| 代理机构 | Tarolli, Sundheim, Covell & Tummino LLP | 代理人 | Tarolli, Sundheim, Covell & Tummino LLP |
| 主权项 | 1. A method of inhibiting adhesion, motility, migration, dispersal, and/or metastasis of a neoplastic, cancer, and/or tumorgenic cell in a subject, the cell expressing pro-prion protein (pro-PrP) and filamin A (FLNa), the method comprising: administering to the cell a therapeutically effective amount of a pro-PrP regulating agent, the pro-PrP regulating agent comprising a peptide that inhibits binding of pro-PrP and FLNa in the cell, the peptide consisting of 5 to 16 amino acids and including an amino acid sequence selected from the group consisting of SEQ ID NO: 4, SEQ ID NO: 5, and SEQ ID NO: 6. | ||
| 地址 | Cleveland OH US | ||