Substituted xanthine derivatives

摘要

This invention relates to novel compounds that are substituted xanthine derivatives and pharmaceutically acceptable salts thereof. For example, this invention relates to novel substituted xanthine derivatives that are derivatives of pentoxifylline. This invention also provides compositions comprising one or more compounds of this invention and a carrier and the use of the disclosed compounds and compositions in methods of treating diseases and conditions for which pentoxifylline and related compounds are beneficial.

主权项

1. A method of treating a disease or condition in a patient in need thereof, comprising administering to the patient an effective amount of a compound represented by the following structural formula:or a pharmaceutically acceptable salt thereof, wherein R1 is selected from —CH3 and —CD3; R2 is selected from —CH3 and —CD3; Y1 is deuterium or hydrogen, wherein the isotopic enrichment factor for each designated deuterium atom is at least 5000, wherein the disease is selected from diabetic nephropathy, hypertensive nephropathy and intermittent claudication on the basis of chronic occlusive arterial disease of the limbs; wherein the compound is administered orally; wherein the compound is administered in an amount of 100-800 mg per treatment; and wherein the treatment is administered two times daily.