| 发明名称 | Peripheral opioid receptor antagonists and uses thereof | ||
| 摘要 | The present invention provides a compound of formula I:; wherein X−, R1, and R2 are as defined herein, and compositions thereof. | ||
| 申请公布号 | US9492445(B2) | 申请公布日期 | 2016.11.15 |
| 申请号 | US201514870323 | 申请日期 | 2015.09.30 |
| 申请人 | Wyeth, LLC | 发明人 | Bazhina Nataliya;Donato, III George Joseph;Fabian Steven R.;Lokhnauth John;Megati Sreenivasulu;Melucci Charles;Ofslager Christian;Patel Niketa;Radebaugh Galen;Shah Syed M.;Szeliga Jan;Zhang Huyi;Zhu Tianmin |
| 分类号 | A61K31/485;A61K31/4748;C07D471/08;C07D489/08;A61K9/00;A61K9/08 | 主分类号 | A61K31/485 |
| 代理机构 | McCarter & English, LLP | 代理人 | McCarter & English, LLP ;Sparks, Esq. Jonathan M.;Gulati, Esq. Manesh |
| 主权项 | 1. A composition comprising a compound of formula III wherein A− is an anion of a Brønsted acid; wherein at least 99.6% of the compound of formula III is in the R configuration; wherein the compound of formula III is contained within a package that is substantially free of tungsten; wherein the composition is substantially free of tungsten; and wherein the composition comprises less than 190 ppm of a compound of formula IIwherein X− is an anion of a Brønsted acid. | ||
| 地址 | Madison NJ US | ||