发明名称 |
4-amino-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one or 4-amino-5,8-dihydropyrido[2,3-d]pyrimidin-7(6H)-one derivatives as activators of the soluble guanylat cyclase for the treatment of cardiovascular diseases |
摘要 |
Compounds of Formula I are capable of modulating the body's production of cyclic guanosine monophosphate (“cGMP”) and are generally suitable for the therapy and prophylaxis of diseases which are associated with a disturbed cGMP balance. The invention furthermore relates to processes for preparing compounds of the Formula I, to their use for the therapy and prophylaxis of the abovementioned diseases and for preparing pharmaceuticals for this purpose, and to pharmaceutical preparations which comprise compounds of the Formula I. |
申请公布号 |
EP2373317(B1) |
申请公布日期 |
2016.12.14 |
申请号 |
EP20090830834 |
申请日期 |
2009.11.16 |
申请人 |
Merck Sharp & Dohme Corp. |
发明人 |
BROCKUNIER, Linda, L.;GUO, Jian;PARMEE, Emma, R.;RAGHAVAN, Subharekha;ROSAUER, Keith;STELMACH, John, E.;SCHMIDT, Darby Rye |
分类号 |
C07D471/04;A61K31/519;A61P9/00;A61P9/04;A61P9/10;A61P9/12;C07D487/04;C07D519/00 |
主分类号 |
C07D471/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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