DIOXACYCLOALKANE COMPOUND WITH RENIN-INHIBITING ACTIVITY

摘要

A dioxacycloalkane compound represented by general formula [1], a pharmaceutically acceptable salt thereof, an intermediate for producing the compound, and a process for producing the intermediate. The compound [1] has a potent activity of inhibiting renin and a persistent hypotensive effect by peroral administration, thus being useful as a hypotensive and a remedy for cardiac insufficiency. General formula [1] wherein A represents [a] or [b]; W represents [c], [d] or [e], X represents -CO- or -SO2-; Y represents -CH2, -O- or -NR25-; R1 represents aralkyl which may be substituted by lower alkoxy; R2 represents hydrogen or lower alkyl; R3 represents -(CH¿2?)d-SR?26¿ or [f]; R?4 and R5¿ represent each hydrogen or lower alkyl; and E represents -C(R29)(R30)- or -CH¿2?CH2-.