Sustained release paracetamol composition

摘要

A pharmaceutical composition in the form of a bilayer tablet having a sustained release phase in one layer and an immediate release phase in the other layer, said composition comprising from 600 to 700mg of paracetamol per unit dose and a pharmaceutically acceptable carrier, characterised in having an in vitro paracetamol dissolution profile (as determined by the USP type III apparatus, reciprocating basket, with 250ml of 0.1M HCl at 37C set at a cycle speed of 15 strokes/min) with the following constraints: 30 to 48% released after 15 minutes; 56 to 75% released after 60 minutes; >85% released after 180 minutes.