发明名称 |
Residual solvent extraction method and microparticles produced thereby |
摘要 |
Methods for preparing microparticles having reduced residual solvent levels. Microparticles are contacted with a non-aqueous washing system to reduce the level of residual solvent in the microparticles. Preferred non-aqueous washing systems include 100% ethanol and a blend of ethanol and heptane. A solvent blend of a hardening solvent and a washing solvent can be used to harden and wash microparticles in a single step, thereby eliminating the need for a post-hardening wash step.
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申请公布号 |
US6824822(B2) |
申请公布日期 |
2004.11.30 |
申请号 |
US20010942631 |
申请日期 |
2001.08.31 |
申请人 |
ALKERMES CONTROLLED THERAPEUTICS INC. II |
发明人 |
RICKEY MICHAEL E.;RAMSTACK J. MICHAEL;KUMAR RAJESH |
分类号 |
B65D5/462;A61K9/16;A61K31/519;A61K38/00;A61K38/04;A61K47/32;A61K47/34;B01J8/02;B01J13/08;B01J13/12;B01J13/20;B01J14/00;B01J19/12;B01J19/24;B65D5/46;B65D5/465;B65D71/00;B65D71/36;(IPC1-7):B01J13/12 |
主分类号 |
B65D5/462 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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