TISSUE REPAIR DEVICES AND SCAFFOLDS

摘要

The present invention relates to multiphasic, three-dimensionally printed, tissue repair devices or scaffolds useful for promoting bone growth and treating bone fracture, defect or deficiency, methods for making the same and methods for promoting bone growth and treating bone fracture, defect or deficiency using the same. The scaffold has a porous bone ingrowth area containing interconnected struts surrounded by a microporous shell. At the ends of the scaffold, the shell may be extended as a guide flange to stabilize the scaffold between ends of bone. The center of the scaffold may be empty and may serve as a potential marrow space.

主权项

1. A tissue repair device or scaffold having a porous bone ingrowth structure containing interconnected struts surrounded by a microporous shell wherein the tissue repair device or scaffold contains therein or thereon a therapeutically effective amount of an adenosine receptor agonist, an adenosine receptor antagonist, or an agent that upregulates, increases the amount of or increases the biological activity of adenosine or an analog or derivative thereof.