发明名称 |
POLYCATIONIC AMPHIPHILES AS ANTIMICROBIAL AGENTS |
摘要 |
The present disclosure provides an antimicrobial composition including a polycationic amphiphile compound, and the method of making and the method of using such a compound or composition. The compound having the formula (I) or (II) R1, R2, R3, R4, R5, R6, R10, or R11 is H or a C1-12 alkyl unsubstituted or optionally substituted with a functional group such as —OH, —OR′, —NH2, —NHR′, —NR′2, —N—C(0)R′, —N—C(0)CR′═CR′, —SH, —SR′, -0-C(0)R′, —C(0)R′, —CF3, —OCF3, halogen, benzyl, o-vinylbenzyl, m-vinylbenzyl, p-vinylbenzyl, phenyl, allyl, and substituted allyl. R7, R8 or R9 is a C1-12 alkyl unsubstituted or optionally substituted with a functional group such as —OH, —OR′, —NH2, —NHR′, —NR′2, —SH, —SR′, -0-C(0)R′, —C(0)R′, —CF3, and —OCF3. R′ is H or a C1-4 alkyl. X or Y is a halogen, m and n are integers in the range from 1 to 25. |
申请公布号 |
US2016262384(A1) |
申请公布日期 |
2016.09.15 |
申请号 |
US201415034375 |
申请日期 |
2014.11.05 |
申请人 |
TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION ;VILLANOVA UNIVERSITY |
发明人 |
WUEST William;MINBIOLE Kevin Patrick |
分类号 |
A01N33/12;A01N25/08 |
主分类号 |
A01N33/12 |
代理机构 |
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代理人 |
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主权项 |
1. An antimicrobial composition comprising a compound having the formula wherein: R1, R2, R3, R4, R5, R6, R10, or R11 is H or a C1-12 alkyl unsubstituted or optionally substituted with a functional group selected from the group consisting of —OH, —OR′, —NH2, —NHR′, —NR′2, —N—C(O)R′, —N—C(O)CR′═CR′, —SH, —SR′, —O—C(O)R′, —C(O)R′, —CF3, —OCF3, halogen, benzyl, o-vinylbenzyl, m-vinylbenzyl, p-vinylbenzyl, phenyl, allyl, and substituted allyl; R7, R8 or R9 is a C1-12 alkyl unsubstituted or optionally substituted with a functional group selected from the group consisting of —OH, —OR′, —NH2, —NHR′, —NR′2, —SH, —SR′, —O—C(O)R′, —C(O)R′, —CF3, and —OCF3; R′ is H or a C1-4 alkyl; X or Y is a halogen; and m and n are integers in the range from 1 to 25. |
地址 |
Philadelphia PA US |