DPY-30 Binding Peptides

摘要

Disclosed are compositions and methods for modulating Dpy-30 binding activity. The compositions may include peptides or peptidomimetics thereof that are related to RSP3 or Ash2L and that bind to Dpy-30.

主权项

1. A peptide of no more than about 50 amino acids, the peptide comprising SEQ ID NO:2, SEQ ID NO:4, or SEQ ID NO:6 or a variant thereof having at least 80% sequence identity to SEQ ID NO:2, SEQ ID NO:4, or SEQ ID NO:6, wherein the variant binds to Dpy-30 with a Kd of less than about 100 nM.