COMPOSITIONS COMPRISING A BIOCIDAL POLYAMINE

摘要

Compounds, compositions, and methods comprising a polyamine compound are described, which may be used to kill, disperse, treat, or reduce biofilms, or to inhibit or substantially prevent biofilm formation. In certain aspects, the present invention relates to compounds, compositions, and methods comprising polyamine compounds that have antimicrobial or dispersing activity against a variety of bacterial strains capable of forming biofilms.

主权项

1. An anti-biofilm composition, the composition comprising
(i) a carrier; and (ii) a biocidal polyamine compound of the formula:or a salt thereof;wherein:
each Ra is an independently selected group of the formula: each Rm is —CR2aR2b—, each R2a and R2b is a member independently selected from the group consisting of hydrogen, alkyl, and fluoroalkyl; or, alternatively, R2a and R2b join to form a spirocycloalkyl ring; each R3 is a member independently selected from the group consisting of —Z1—Y1—R4 and —Z1—Y1—Y2—R4; each R4 is a member independently selected from the group consisting of hydrogen, alkyl, fluoroalkyl, alkenyl, alkynyl, arylalkyl, and heteroarylalkyl; each Y1 and Y2 is an independently selected group of the formula: each Z1 and Z2 is an independently selected NR4; and wherein the biocidal polyamine compound comprises at least four primary or secondary amino groups.