| 摘要 |
The invention concerns <i>in vivo</i> and <i>in vitro</i> expression vectors comprising a polynucleotide coding for the structural protein E of the Nile fever virus or the WN virus, optionally associated with a polynucleotide coding for the pre-membrane protein prM and/or for the membrane protein M, in particular in the form coding for prM-M-E. Said <i>in vivo</i> expression vectors are incorporated in live vaccines. The <i>in vivo</i> expression vectors are used for producing <i>in vitro</i> proteins which can then be used in subunit vaccines. The invention also concerns multivalent vaccines comprising a vaccine constituent against the WN virus and a vaccine constituent against another pathogen. The invention is particular designed for horses, dogs, cats, cattle, pigs and birds. |
